PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4096)
Related Products (4096)
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PROTAC Linkers Isoform Comparison
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Boc-NH-bicyclo[1.1.1]pentane-C-NH2
![Boc-NH-bicyclo[1.1.1]pentane-C-NH2](https://file.medchemexpress.com/product_pic/hy-w056112.gif "Click to View Boc-NH-bicyclo[1.1.1]pentane-C-NH2 Product Detail")
0 ImagesCat. No.: HY-W056112CAS No.: 1638765-05-5
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Bicyclo[2.2.2]octane-1,4-dicarboxylic acid
![Bicyclo[2.2.2]octane-1,4-dicarboxylic acid](https://file.medchemexpress.com/product_pic/hy-w001268.gif "Click to View Bicyclo[2.2.2]octane-1,4-dicarboxylic acid Product Detail")
0 ImagesCat. No.: HY-W001268CAS No.: 711-02-4
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Undec-10-ynoic acid
0 ImagesSynonyms: 10-Undecynoic acid
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tert-Butyl N-{2-azaspiro[3.4]octan-6-yl}carbamate
![tert-Butyl N-{2-azaspiro[3.4]octan-6-yl}carbamate](https://file.medchemexpress.com/product_pic/hy-w056054.gif "Click to View tert-Butyl N-{2-azaspiro[3.4]octan-6-yl}carbamate Product Detail")
0 ImagesCat. No.: HY-W056054CAS No.: 1638761-24-6
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Boc-C7-COOH
0 ImagesCat. No.: HY-W088194CAS No.: 1290540-34-9
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tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W071973CAS No.: 177276-41-4
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tert-Butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylate
![tert-Butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylate](https://file.medchemexpress.com/product_pic/hy-w056269.gif "Click to View tert-Butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylate Product Detail")
0 ImagesCat. No.: HY-W056269CAS No.: 1272758-41-4
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Propargyl-PEG3-NHS ester
0 ImagesCat. No.: HY-126974CAS No.: 1428629-71-3Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG3-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Amino-PEG4-C1-Boc
0 ImagesCat. No.: HY-42619CAS No.: 864680-64-8
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N-Boc-PEG5-bromide
0 ImagesN-Boc-PEG5-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Propargyl-PEG3-bromide
0 ImagesCat. No.: HY-140036CAS No.: 203740-63-0
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Amino-PEG6-alcohol
0 ImagesAmino-PEG6-alcohol is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG6-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
